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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：407255
- cas：312636-16-1
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 407255 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; |
| CAS編號 | 312636-16-1 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells.
Synonym: SKI-II; SKI II. Sphingosine kinase inhibitor II;
IUPAC/Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
InChi Key: ZFGXZJKLOFCECI-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
SMILES Code: OC1=CC=C(NC2=NC(C3=CC=C(Cl)C=C3)=CS2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
