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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：532798
- cas：326914-10-7
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 532798 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 25.0mg; |
| CAS編號(hào) | 326914-10-7 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: SU11652 is a potent cell-permeable pyrrole-indolinone compound that acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 >20 μM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells.
Name: SU11652
CAS#: 326914-10-7
Chemical Formula: C22H27ClN4O2
Exact Mass: 414.1823
Molecular Weight: 414.93
Elemental Analysis: C, 63.68; H, 6.56; Cl, 8.54; N, 13.50; O, 7.71
Synonym: SU11652; SU 11652; SU-11652.
IUPAC/Chemical Name: 5-{[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
InChi Key: XPLJEFSRINKZLC-ATVHPVEESA-N
InChi Code: InChI=1S/C22H27ClN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
SMILES Code: O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(Cl)C=C3)=O)=C1C)NCCN(CC)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
